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All these clinical safety data are consistent with the published Leiter II 24-month follow-up study data and support that Jintrolong® can increase convenience and compliance in GHD children without increasing safety concerns.

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Intergroup comparisons were performed using analysis of covariance (ANCOVA). The change from baseline efficacy endpoints at week 52 was tested for superiority of somatropin to no treatment using least squares mean (LSM) difference. There is evidence of superiority if the 95% confidence interval (CI) for the treatment effect lies entirely above zero. AEs were summarized descriptively by severity and relationship to somatropin.

Figure 6 shows representative images of CP tissue stained with an antibody against Ki-67. There are only a few positive cells (+) or no positive cells (−) in the brain CP tissue of cynomolgus monkeys hinein most animals, except for one animal hinein the 3 mg/kg/week group, which had multiple positive check here cells hinein the CP(++).

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Findings on the slides were scored and categorized using a standardized nomenclature. A four-step grading Gebilde of sehr wenig, mild, moderate, or severe was used to gerade the severity of microscopic lesions for comparison among groups. Pathology assessments were double-blind; the pathologists were given only monkey numbers without any monkey grouping information.

θj is the serum concentration observed in the ith individual at time j, θj is the predicted concentration, ϵ is the proportional error, and ξ is the additional error. Assume that the ϵ and ξ are normally distributed with the mean of zero and the variance of σϵ2 and σξ2.

Since vacuolation did not obviously affect the subcellular structure or cell proliferation of CP epithelial cells, the next question is whether the vacuolation rein CP affected the function of CP epithelial cells and the brain. The indices of CP function measured were secreted CSF and cell metabolism of glucose.

Mild side effects allow combining Jintropin with a large number of other drugs, which gives a truly amazing result.

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Whole-brain slides were checked. Positive PEG staining welches only detected in CP and blood vessels (Figure 4G) but not rein other brain tissues, indicating that PEG or Jintrolong® welches unlikely to cross the blood-brain barrier composed of CP cells and enter other brain tissue.